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In the article, Hill argued that there is little evidence that, at a population level, cannabis use during adolescence is a primary contributing factor in the development of psychiatric illness. But he also noted that there is evidence that in high-risk populations, cannabis can be highly adverse, so arguments claiming that cannabis is innocuous are equally flawed. Weed affects people with schizophrenia differently When The Verge asked about the risks associated with cannabis use, Hill said that "there are detailed studies which have demonstrated that cannabis can have very different effects on the brain of someone who is at risk for schizophrenia than someone who isn't." One 2013 study, for instance, demonstrated that the increased release of dopamine from smoking marijuana is amplified in the brains of people with schizophrenia, as well as in their close relatives

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